Chloroacetone → 2-Propanone, 1-((1-methyl-1H-tetrazol-5-yl)thio)-
反応式
O.[Na].[SH:3][C:4]1[N:8]([CH3:9])[N:7]=[N:6][N:5]=1.Cl[CH2:11][C:12](=[O:14])[CH3:13]>C(O)C>[CH3:9][N:8]1[C:4]([S:3][CH2:11][C:12]([CH3:13])=[O:14])=[N:5][N:6]=[N:7]1参加物
4
実験手順
To a solution of 3.12 g (0.02 mol) of 5-mercapto-1-methyltetrazole sodium salt hydrate in 60 ml of absolute ethanol was added dropwise, 2.06 g (0.2 mol) of chloroacetone. After stirring for 20 hours at room temperature, the ethanol was evaporated in vacuo. The residue was dissolved in methylene chloride and was washed with water and then brine prior to drying over Na2SO4. Evaporation of the methylene chloride solution gave 1-methyl-5-acetonylthiotetrazole that was purified by flash chromatography on silica gel to yield 0.94 g of the 5-acetonylthio-1-methyltetrazole product.
後処理
- customthe ethanol was evaporated in vacuo
- dissolutionThe residue was dissolved in methylene chloride
- washwas washed with water
- dry with materialbrine prior to drying over Na2SO4
- customEvaporation of the methylene chloride solution
出典と根拠
- ORDレコード
- ord-69deeb1296234ed9a1deaa3df3afcd02
- 出典データセット
- uspto-grants-1991_09
- 特許番号
- US05047416
反応ノート
読み込み中…