Sodium Cyanide → 3-Methoxy-5-methylthio-4-propoxyphenyl acetonitrile

HRID 728062ノート

反応式

HRID 728062 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([S:15][CH3:16])[C:10]=1[O:11][CH2:12][CH2:13][CH3:14])[CH2:6]Cl.[C-:17]#[N:18].[Na+]>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:6][C:17]#[N:18])[CH:8]=[C:9]([S:15][CH3:16])[C:10]=1[O:11][CH2:12][CH2:13][CH3:14]

参加物

4

反応物 2

HCID 8929Sodium CyanideHCID 15044966HCID 15044966、化合物

生成物 1

HCID 150449673-Methoxy-5-methylthio-4-propoxyphenyl acetonitrile収率 95%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To 16 g of 3-methoxy-5-methylthio-4-propoxybenzyl chloride in 100 ml of dry DMF was added 5 g (0.10 mole) sodium cyanide. The mixture was stirred for about 48 hours at room temperature under N2. The solution was filtered, and the filtrate was concentrated under vacuum. The residue was purified by flash column chromatography to yield 14.5 g of 3-methoxy-5-methylthio-4-propoxyphenyl acetonitrile as an oil. (95% yield).

後処理

  1. filtrationThe solution was filtered
  2. concentrationthe filtrate was concentrated under vacuum
  3. customThe residue was purified by flash column chromatography

出典と根拠

ORDレコード
ord-96dc13ddc31b44d1927471b29f0b28b2
出典データセット
uspto-grants-1991_09
特許番号
US05047420

反応ノート

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