Hydrochloric Acid → 2-(3,4-Bis(benzyloxy)phenyl)acetic acid

HRID 728073ノート

反応式

HRID 728073 の反応式
[OH-].[K+].[CH2:3]([O:10][C:11]1[CH:12]=[C:13]([CH2:25][C:26]([O:28]CC2C=CC=CC=2)=[O:27])[CH:14]=[CH:15][C:16]=1[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl>CO>[CH2:3]([O:10][C:11]1[CH:12]=[C:13]([CH2:25][C:26]([OH:28])=[O:27])[CH:14]=[CH:15][C:16]=1[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 419522HCID 419522、化合物

生成物 1

HCID 5618122-(3,4-Bis(benzyloxy)phenyl)acetic acid収率 78.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Potassium hydroxide (6.2 g) was added to a solution of benzyl 3,4-dibenzyloxyphenylacetate (16.0 g) in methanol (200 ml), followed by stirring at room temperature for 6 hours. The reaction mixture was adjusted to pH 4.0 with 5N hydrochloric acid solution. The solvent was distilled off and to the residue was added water. The precipitated crystal was collected by filtration, washed with water and dried to obtain as colorless crystal 3,4-dibenzyloxyphenylacetic acid (10.0 g).

後処理

  1. distillationThe solvent was distilled off and to the residue
  2. additionwas added water
  3. filtrationThe precipitated crystal was collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-a73f8cf75ef24949afbfa02650c3f78c
出典データセット
uspto-grants-1991_09
特許番号
US05047430

反応ノート

読み込み中…