Hydrochloric Acid → 2-Ethylamino-6-[2-(2-imidazolyl)ethyl]benzoxazole

関与物質

反応手順

10% Palladium on carbon (0.5 g) was added to a mixture of 6-[2-[1-benzylimidazol-2-yl)vinyl]-2-ethylaminobenzoxazole (0.9 g) in a solution of methanol (50 ml) and conc. hydrochloric acid (6 ml), and the mixture was subjected to catalytic reduction under atmospheric pressure for 6 hours at ambient temperature. The catalyst was removed by filtration and the filtrate was evaporated in vacuo. The residue was purified by a column chromatography on alumina and eluted with a chloroform. The eluted fractions containing the desired product were collected and evaporated in vacuo. The residue was triturated with diethyl ether to give 2-ethylamino-6-[2-(2-imidazolyl)ethyl]benzoxazole (0.13 g).

情報源と証拠