Ethanol → 2-(2-Phenylethyl)malonic acid

HRID 728243

反応式

HRID 728243 の反応式
[CH2:1]([CH2:8][CH:9]([C:15]([O:17]CC)=[O:16])[C:10]([O:12]CC)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)C.[OH-].[K+]>O>[CH2:1]([CH2:8][CH:9]([C:15]([OH:17])=[O:16])[C:10]([OH:12])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 811191,3-Diethyl 2-(2-phenylethyl)propanedioate

生成物 1

HCID 1012342-(2-Phenylethyl)malonic acid収率 83.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The diethyl benzylmethylmalonate (75 g) was combined with 300 ml of ethanol and a solution of 100 g potassium hydroxide in 300 ml of water and heated to a gentle reflux for 5 hours. After cooling, the mixture was extracted with diethyl ether (2×300 ml). The aqueous phase was then acidified with 120 ml concentrated hydrochloric acid, and extracted with diethyl ether (3×300 ml). The combined organic extracts were dried over magnesium sulfate, filtered and concentrated to yield 49.2 g of benzylmethylmalonic acid as a yellow solid (83% yield).

後処理

  1. temperaturea gentle reflux for 5 hours
  2. temperatureAfter cooling
  3. extractionthe mixture was extracted with diethyl ether (2×300 ml)
  4. extractionextracted with diethyl ether (3×300 ml)
  5. dry with materialThe combined organic extracts were dried over magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-0e4329d6eaf04e58822bc164c4060b08
出典データセット
uspto-grants-1991_09
特許番号
US05047534

関連ノート

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