Water → 2-Bromo-1-[1-(4-Chlorophenyl)cyclobutyl]ethanone

HRID 728290ノート

反応式

HRID 728290 の反応式
[Br:1]Br.[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2([C:14](=[O:16])[CH3:15])[CH2:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1.O>ClCCl.CO>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2([C:14](=[O:16])[CH2:15][Br:1])[CH2:13][CH2:12][CH2:11]2)=[CH:8][CH:9]=1

参加物

6

反応物 3

HCID 962WaterHCID 24408BromineHCID 212584081-[1-(4-Chlorophenyl)cyclobutyl]ethanone

生成物 1

HCID 219019212-Bromo-1-[1-(4-Chlorophenyl)cyclobutyl]ethanone

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6344Dichloromethane溶媒

実験手順

A solution of bromine (8 ml) in dichloromethane (40 ml) was added at 10° C. to a solution of 1-[1-(4-chlorophenyl)cyclobutyl]ethanone (27.8 g) in methanol (30 ml). The mixture was stirred for 15 minutes and poured into a mixture of ice and water. The resulting mixture was extracted with dichloromethane. The extract was washed with water, dried and evaporated to yield an oil which was distilled (145°-160° C./1mm Hg) to give 1-[1-(4-chlorophenyl)cyclobutyl]-2-bromoethanone.

後処理

  1. extractionThe resulting mixture was extracted with dichloromethane
  2. washThe extract was washed with water
  3. customdried
  4. customevaporated
  5. customto yield an oil which
  6. distillationwas distilled (145°-160° C./1mm Hg)

出典と根拠

ORDレコード
ord-bd99a7586f3746e1b860ebe0d6881eef
出典データセット
uspto-grants-1991_09
特許番号
US05047432

反応ノート

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