Hydrochloric Acid → HCID 19823951、化合物

HRID 728408ノート

反応式

HRID 728408 の反応式
[N+:1]([C:4]1[CH:10]=[C:9]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH:8]=[CH:7][C:5]=1[NH2:6])([O-:3])=[O:2].C(O)(=O)CC.Cl.[N:29]([O-])=O.[Na+].[CH3:33][N:34]([CH2:41][CH2:42][C:43]([OH:45])=[O:44])[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1.C([O-])(=O)C.[Na+]>C(O)(=O)C.O>[N+:1]([C:4]1[CH:10]=[C:9]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH:8]=[CH:7][C:5]=1[N:6]=[N:29][C:38]1[CH:39]=[CH:40][C:35]([N:34]([CH3:33])[CH2:41][CH2:42][C:43]([OH:45])=[O:44])=[CH:36][CH:37]=1)([O-:3])=[O:2]

参加物

9

反応物 6

HCID 313Hydrochloric Acid2 回HCID 1032Propionic AcidHCID 517045Sodium AcetateHCID 125224893-(Methylphenylamino)-propionic acidHCID 141221844-Dodecyl-2-nitroanilineHCID 23668193Sodium Nitrite

生成物 1

HCID 19823951HCID 19823951、化合物収率 4%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

反応条件

温度
0 °C

実験手順

2-Nitro-4-dodecylaniline (3.06 g) was dissolved in acetic acid (15 ml) and propionic acid (15 ml) and warmed whilst dilute hydrochloric acid (5 ml) was added. The mixture was cooled to 0° C. and sodium nitrite (0.7 g) was added at 0° C. The diazotised amine was then added to N-methyl-N-(2-hydroxycarbonylethyl)aniline (1.79 g) in water (100 ml) with dilute hydrochloric acid (3 ml). Sodium acetate was added until colour developed and the mixture was stirred for 0.5 hours. The crude product was recrystallised from CH2Cl2 to give a red solid (0.2 g).

後処理

  1. additionwas added
  2. customThe crude product was recrystallised from CH2Cl2

出典と根拠

ORDレコード
ord-4deca5fba76847d99c067e762b2e0a36
出典データセット
uspto-grants-1991_09
特許番号
US05047516

反応ノート

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