Acetylpyrazine → Propanoic acid [1-(2-pyrazinyl)ethylidene]hydrazide

HRID 728545ノート

反応式

HRID 728545 の反応式
[C:1]([C:4]1[CH:9]=[N:8][CH:7]=[CH:6][N:5]=1)(=O)[CH3:2].[C:10]([NH:14][NH2:15])(=[O:13])[CH2:11][CH3:12]>C(O)C>[N:5]1[CH:6]=[CH:7][N:8]=[CH:9][C:4]=1[C:1](=[N:15][NH:14][C:10](=[O:13])[CH2:11][CH3:12])[CH3:2]

参加物

4

反応物 2

HCID 30914AcetylpyrazineHCID 79890Propionylhydrazine

生成物 1

HCID 54558617Propanoic acid [1-(2-pyrazinyl)ethylidene]hydrazide収率 64.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 6.11 gm (0.05 mole) of 2-acetylpyrazine, 4.41 gm (0.05 mole) of propanoic acid hydrazide and 100 ml of absolute ethanol is refluxed 10 hr. The mixture is cooled. The white crystals which deposit are collected and dried to yield 6.17 gm (64%) of the title compound having a melting point of 181.3° C.

後処理

  1. temperatureis refluxed 10 hr
  2. temperatureThe mixture is cooled
  3. customThe white crystals which deposit are collected
  4. customdried

出典と根拠

ORDレコード
ord-634a163bfca84dbcb8aac450056b0f69
出典データセット
uspto-grants-1991_09
特許番号
US05049561

反応ノート

読み込み中…