3-Quinolinecarboxylic acid, 4-chloro-8-methoxy-, ethyl ester → Ethyl 8-methoxy-4-(4-methoxy-3-thienylamino)quinoline-3-carboxylate

HRID 728550ノート

反応式

HRID 728550 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[CH:10][C:9]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:8]2Cl.[CH3:19][O:20][C:21]1[C:22]([NH2:26])=[CH:23][S:24][CH:25]=1>O1CCOCC1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[CH:10][C:9]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:8]2[NH:26][C:22]1[C:21]([O:20][CH3:19])=[CH:25][S:24][CH:23]=1

参加物

4

反応物 2

HCID 3045573-Quinolinecarboxylic acid, 4-chloro-8-methoxy-, ethyl esterHCID 149896854-Methoxythiophen-3-amine

生成物 1

HCID 14989686Ethyl 8-methoxy-4-(4-methoxy-3-thienylamino)quinoline-3-carboxylate

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Ethyl 8-methoxy-4-chloroquinoline-3-carboxylate (1.5 g, 0.0056 mol) and 4-methoxy-3-aminothiophene (1.46 g, 0.0112 mol) in 1,4 dioxan (20 ml) were heated under reflux for 4 hours. The solid which had formed was collected by filtration and dried. The solid was dissolved in chloroform, washed with sodium carbonate solution (50 ml), then water, dried over magnesium sulphate, filtered and evaporated under reduced pressure to give a yellow solid.

後処理

  1. temperatureunder reflux for 4 hours
  2. customThe solid which had formed
  3. filtrationwas collected by filtration
  4. customdried
  5. dissolutionThe solid was dissolved in chloroform
  6. washwashed with sodium carbonate solution (50 ml)
  7. dry with materialwater, dried over magnesium sulphate
  8. filtrationfiltered
  9. customevaporated under reduced pressure
  10. customto give a yellow solid

出典と根拠

ORDレコード
ord-0b3ab8237b4a49fbb0f2a915dc98235a
出典データセット
uspto-grants-1991_09
特許番号
US05049567

反応ノート

読み込み中…