Fumaric Acid → 10-[(2RS)-1-diethylamino-2-propyl]-N-(2-methylpropyl)-2-phenothiazinecarboxamide fumarate
反応式
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[CH2:9]([N:11]([CH2:36][CH3:37])[CH2:12][CH:13]([N:15]1[C:28]2[CH:27]=[C:26]([C:29]([NH:31][CH2:32][CH:33]([CH3:35])[CH3:34])=[O:30])[CH:25]=[CH:24][C:23]=2[S:22][C:21]2[C:16]1=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH3:14])[CH3:10]>CC(O)C>[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[CH2:36]([N:11]([CH2:9][CH3:10])[CH2:12][CH:13]([N:15]1[C:28]2[CH:27]=[C:26]([C:29]([NH:31][CH2:32][CH:33]([CH3:35])[CH3:34])=[O:30])[CH:25]=[CH:24][C:23]=2[S:22][C:21]2[C:16]1=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH3:14])[CH3:37]参加物
4
実験手順
Fumaric acid (0.18 g) dissolved in 2-propanol (7.5 cc) under reflux is added to a solution of 10-[(2RS)-1-diethylamino-2-propyl]-N-(2-methylpropyl)-2-phenothiazinecarboxamide (0.62 g) in boiling 2-propanol (7.5 cc). The mixture is concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 40° C. and the residue is stirred in isopropyl ether (50 cc). The solid is separated by filtration on sintered glass, washed with isopropyl ether (10 cc) and dried under reduced pressure (5 mm Hg; 0.7 kPa) to give 10-[(2RS)-1-diethylamino-2-propyl]-N-(2-methylpropyl)-2-phenothiazinecarboxamide fumarate (0.64 g), m.p. 110° C.