Formic Acid → N-(2-Pyrimidinyl)-formamide
反応式
[N+:1]([C:4]1[N:9]=[CH:8][CH:7]=[CH:6][N:5]=1)([O-])=O.[CH:10](O)=[O:11].S(S([O-])=O)([O-])=O.[Na+].[Na+].C>C(N)=O.O>[CH:10]([NH:1][C:4]1[N:9]=[CH:8][CH:7]=[CH:6][N:5]=1)=[O:11]参加物
7
実験手順
The crude nitropyrimidine (25.32 g) from above was suspended in formamide (150 ml) and 90% formic acid (50 ml) and the suspension was warmed to 70° C. in a water bath. Sodium dithionite was carefully added to the warm suspension and then boiled for 15-20 minutes. The reaction mixture was diluted with hot water (300 ml), treated with charcoal and then boiled for an additional 20-25 minutes, filtered through celite, cooled and concentrated under reduced pressure to give formamido-pyrimidine which was collected by filtration, washed with acetone, and dried under vacuum at 56° C.
後処理
- waitboiled for an additional 20-25 minutes
- filtrationfiltered through celite
- temperaturecooled
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-c46ab75fdd594a259230d073dd0aae3c
- 出典データセット
- uspto-grants-1991_09
- 特許番号
- US05051429
反応ノート
読み込み中…