関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Propionyl chloride | HCID 62324 | — |
| 反応物 | N1,N1-Dibenzylethane-1,2-diamine | HCID 6394114 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-[2-[bis(Phenylmethyl)amino]ethyl]-propanamide | HCID 54327882 | — |
反応手順
To a chilled solution of 5.0 g (21 mmol) N,N-dibenzylethylenediamine and 30mL (21 mmol) triethylamine in 20 mL THF is added 1.8 mL (21 mmol) propionylchloride, dropwise. The temperature of the reaction mixture is maintained below 0° C. during addition. The reaction mixture is stirred for 30minutes at 0° C. After this time, the reaction mixture is filtered and the solvents are evaporated to give the product which can be purified via column chromatography.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05051423 |
|---|
| 出典データセット | uspto-grants-1991_09 |
|---|
| ORD ID | ord-6c796ddafef5454ba34e40ccd9db3930 |
|---|
| 出典メモ | uspto-grants-1991_09 |
|---|
