Methanol → N-[4-[[2-Hydroxy-3-(3-methylphenoxy)propyl]aminomethyl]phenyl]methanesulfonamide hydrochloride

HRID 728824ノート

反応式

HRID 728824 の反応式
[ClH:1].[NH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][S:11]([CH3:14])(=[O:13])=[O:12])=[CH:6][CH:5]=1.[O:15]1[CH:17]([CH2:18][O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:16]1.O.[CH3:27]O>[OH-].[K+]>[ClH:1].[OH:15][CH:17]([CH2:18][O:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH3:27])[CH:21]=1)[CH2:16][NH:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]([NH:10][S:11]([CH3:14])(=[O:13])=[O:12])=[CH:8][CH:9]=1

参加物

6

反応物 4

HCID 887MethanolHCID 962WaterHCID 31217Phenyl glycidyl etherHCID 27609964-(Methylsulfonylamino)benzylamine hydrochloride

生成物 1

HCID 67689925N-[4-[[2-Hydroxy-3-(3-methylphenoxy)propyl]aminomethyl]phenyl]methanesulfonamide hydrochloride

試薬・触媒・溶媒 1

HCID 14797Potassium Hydroxide溶媒

実験手順

Heat a mixture of N-[4-(aminomethyl)phenyl]methanesulfonamide hydrochloride(15.0 g, 63.4 mmol) and 1,2-epoxy-3-phenoxypropane (10.41 g, 63.4 mmol) in 63.4 mL of 1 N KOH in methanol and 10 mL of water for about 3.5 h. Remove the solvent to afford crystals of the title compound.

後処理

  1. temperatureHeat
  2. customRemove the solvent

出典と根拠

ORDレコード
ord-a803a23f20484de38099ab35d2c71d98
出典データセット
uspto-grants-1991_09
特許番号
US05051423

反応ノート

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