2-((1-Naphthalenyloxy)methyl)oxirane → 1-[2-Hydroxy-3-(1-naphthalenyloxy)propyl]-4-[4-[(methylsulfonyl)amino]benzoyl]piperazine

HRID 728830ノート

反応式

HRID 728830 の反応式
[O:1]1[CH:3]([CH2:4][O:5][C:6]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=[CH:8][CH:7]=2)[CH2:2]1.[CH3:16][S:17]([NH:20][C:21]1[CH:34]=[CH:33][C:24]([C:25]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[O:26])=[CH:23][CH:22]=1)(=[O:19])=[O:18]>CO>[OH:1][CH:3]([CH2:4][O:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8][CH:7]=1)[CH2:2][N:30]1[CH2:31][CH2:32][N:27]([C:25](=[O:26])[C:24]2[CH:33]=[CH:34][C:21]([NH:20][S:17]([CH3:16])(=[O:19])=[O:18])=[CH:22][CH:23]=2)[CH2:28][CH2:29]1

参加物

4

反応物 2

HCID 915212-((1-Naphthalenyloxy)methyl)oxiraneHCID 147398841-[4-[(Methylsulfonyl)amino]benzoyl]piperazine

生成物 1

HCID 147398851-[2-Hydroxy-3-(1-naphthalenyloxy)propyl]-4-[4-[(methylsulfonyl)amino]benzoyl]piperazine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Add 7.89 g (42.4 mmol) of 1,2-epoxy-3-(1-naphthalenyloxy)propane to a solution of 12.0 9 (42.4 mmol) of 1-[4-[(methylsulfonyl)amino]benzoyl]piperazine in methanol. Heat the resultant solution at reflux for about 46 h. Cool the solution to room temperature and evaporate the solvent. Triturate the residue with ether toobtain crystals of the title compound.

後処理

  1. temperatureat reflux for about 46 h
  2. customevaporate the solvent
  3. customTriturate the residue with ether toobtain crystals of the title compound

出典と根拠

ORDレコード
ord-eecd2b2f781d4955ac837ac98093689d
出典データセット
uspto-grants-1991_09
特許番号
US05051423

反応ノート

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