Trimethyl phosphite → HCID 21612902、化合物

反応式

[CH2:1]([O:3][C:4](=[O:14])[CH:5]([NH:11][CH:12]=[O:13])[CH:6](O)[C:7]([CH3:9])=[CH2:8])[CH3:2].S(Br)(Br)=O.[P:19]([O:24]C)([O:22][CH3:23])[O:20][CH3:21]>>[CH2:1]([O:3][C:4](=[O:14])[CH:5]([NH:11][CH:12]=[O:13])/[CH:6]=[C:7](\[CH3:9])/[CH2:8][P:19]([O:22][CH3:23])([O:20][CH3:21])=[O:24])[CH3:2]

参加物

反応物 3

HCID 8472Trimethyl phosphite

HCID 68176Thionyl bromide

HCID 14332470HCID 14332470、化合物

生成物 1

HCID 21612902HCID 21612902、化合物

実験手順

By reaction of 2-formylamino-3-hydroxy-4-methyl-4-pentenoic acid ethyl ester with thionyl bromide and subsequent treatment with trimethyl phosphite in a manner analogous to that described in Example 1, E-2-formylamino-4-methyl-5-dimethylphosphono-3-pentenoic acid ethyl ester is obtained in the form of a pale yellow oil.

出典と根拠

ORDレコード: ord-84dc490d9fe241eaa6515d0195deb6b7
出典データセット: uspto-grants-1991_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05051413

反応ノート

読み込み中…