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Chlorosulfonic acid → 4-(1H-Imidazol-1-yl)benzenesulfonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chlorosulfonic acid | HCID 24638 | — |
| 反応物 | 1-Phenylimidazole | HCID 81595 | — |
| 生成物 | 4-(1H-Imidazol-1-yl)benzenesulfonyl chloride | HCID 14998830 | — |
反応手順
To chlorosulfonic acid cooled to 0° C. in an ice bath is added portionwise 1-phenyl-1H-imidazole. Monitor the progress of the reaction bythin-layer chromatography. When the reaction is complete, quench the mixture on ice. Saturated aqueous NaHCO3 is added until the solution is no longer acidic. Extract the mixture with CH2Cl2. Dry the organic layer over anhydrous Na2SO4 and remove the solvent in vacuo to obtain the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05051422 |
| 出典データセット | uspto-grants-1991_09 |
| ORD ID | ord-6cc879f52e8e41ef9074507710849770 |
| 出典メモ | uspto-grants-1991_09 |