Ethanol → HCID 54280119、化合物
反応式
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[S:8])=[CH:5][CH:4]=1.C(O)C.Cl[CH:16]([CH3:20])[C:17](=O)[CH3:18]>CCOCC>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]2[S:8][C:16]([CH3:20])=[C:17]([CH3:18])[N:9]=2)=[CH:5][CH:4]=1参加物
5
実験手順
To a stirred mixture of 65.1 g (4-methoxy)thiobenzamide and 156 ml ethanol was added dropwise 50.1 g 3-chloro-2-butanone, and the reaction mixture was heated at reflux for 3 hours. An additional 6.1 g 2-chloro-3-butanone was added and heating was continued for an additional hour. The reaction mixture was cooled, 300 ml ether added, and the solid which precipitated was collected and dried to give 74.5 g 2-(4-methoxyphenyl)-4,5-dimethylthiazole in the form of its hydrochloride monohydrate, m.p. 166°-170° C.
後処理
- temperaturethe reaction mixture was heated
- temperatureat reflux for 3 hours
- temperatureheating
- waitwas continued for an additional hour
- temperatureThe reaction mixture was cooled
- customthe solid which precipitated
- customwas collected
- customdried
出典と根拠
- ORDレコード
- ord-b508029375244457a2b8b79ffa047bd7
- 出典データセット
- uspto-grants-1991_09
- 特許番号
- US05051437
反応ノート
読み込み中…