化工社化工社 化学情報印刷レポート · 研究参考用
8,9-Difluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid → Ofloxacin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 8,9-Difluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid | HCID 534278 | — |
| 反応物 | 4-(t-Butyldimethylsilyl)-1-methyl piperazine | HCID 19434781 | — |
| 生成物 | Ofloxacin | HCID 4583 | — |
反応手順
In a manner similar to that of Example 4, 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido [1,2,3-de]-1,4-benzoxazin- 6-carboxylic acid (II, X: fluoro) is reacted with 4-(t-butyldimethylsilyl)-1-methylpiperazine (III, R2, R3 and R4 : methyl; R5 : t-butyl) to obtain a solid compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05051505 |
| 出典データセット | uspto-grants-1991_09 |
| ORD ID | ord-13e9f7b309c54757b66a5042d743ec3c |
| 出典メモ | uspto-grants-1991_09 |