Ammonia → Isopropyl 3-aminopropyl(ethyl)phosphinate
反応式
[C:1]([CH2:3][CH2:4][P:5]([CH2:11][CH3:12])(=[O:10])[O:6][CH:7]([CH3:9])[CH3:8])#[N:2].N.[H][H]>C(O)(C)C.[Ni]>[NH2:2][CH2:1][CH2:3][CH2:4][P:5]([CH2:11][CH3:12])(=[O:10])[O:6][CH:7]([CH3:9])[CH3:8]参加物
6
実験手順
To 34.1 g of isopropyl 2-cyanoethyl(ethyl)phosphinate in 500 ml of isopropanol are added 60 ml of liquid ammonia and 6.8 g of Raney-Nickel. The mixture is heated to 80° and treated with hydrogen at 100 bar. After 11/2 hours hydrogen-uptake stops. The reaction mixture is filtered and the filtrate distilled to give isopropyl 3-aminopropyl(ethyl)phosphinate as a colorless oil, b.p. 75°/13 Pa.
後処理
- temperatureThe mixture is heated to 80°
- filtrationThe reaction mixture is filtered
- distillationthe filtrate distilled
出典と根拠
- ORDレコード
- ord-d9b43e86560e475cbc842b840809ade4
- 出典データセット
- uspto-grants-1991_09
- 特許番号
- US05051524
反応ノート
読み込み中…