Benzo(F)Quinoline → Mls002703342

HRID 729204

反応式

HRID 729204 の反応式
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.C(Cl)Cl.[CH:14]1[C:23]2[C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[CH:20]=[CH:19][C:18]=2[N:17]=[CH:16][CH:15]=1.[C-:28]#[N:29].[K+]>C(Cl)Cl.O>[C:28]([CH:16]1[CH:15]=[CH:14][C:23]2[C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[CH:20]=[CH:19][C:18]=2[N:17]1[C:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)#[N:29]

参加物

7

反応物 4

HCID 6796Benzo(F)QuinolineHCID 7412Benzoyl chlorideHCID 9032Potassium CyanideHCID 21908982Water methylene chloride

生成物 1

HCID 262649Mls002703342

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

648 μl (5.58 mmol) benzoyl chloride was added to a two phase system of water/methylene chloride over a period of two hours. These two layers contain 500 mg (2.79 mmol) of benzo(f)chinolin in the methylene chloride layer and 545 mg (8.37 mmol) KCN in water. Stirring was continued for 6 hours. The organic phase was separated and washed with water, 5% hydrochloric acid, water, 5% NaOH solution, and again with water. After drying over magnesium sulfate, the solution was evaporated to dryness.

後処理

  1. customThe organic phase was separated
  2. washwashed with water, 5% hydrochloric acid, water, 5% NaOH solution
  3. dry with materialAfter drying over magnesium sulfate
  4. customthe solution was evaporated to dryness

出典と根拠

ORDレコード
ord-7edc6e62b38842c4962ead419202b6d3
出典データセット
uspto-grants-2009_09
特許番号
US07582295B2

関連ノート

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