Ammonia → 5-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]pyrazine-2-carboxamide

HRID 729452ノート

反応式

HRID 729452 の反応式
[Br:1][C:2]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[N:12]=[CH:13][C:14]([C:17]([O:19]C)=O)=[N:15][CH:16]=2)[CH2:7][CH2:6]1.[NH3:26]>CO>[Br:1][C:2]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[N:12]=[CH:13][C:14]([C:17]([NH2:26])=[O:19])=[N:15][CH:16]=2)[CH2:7][CH2:6]1

参加物

4

反応物 2

HCID 222AmmoniaHCID 57832729Methyl 5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyrazine-2-carboxylate

生成物 1

HCID 690622895-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]pyrazine-2-carboxamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
55 °C

実験手順

A methanol (30 mL) suspension of methyl 5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyrazine-2-carboxylate from Step 3 (2.00 g, 4.87 mmol) in a sealed tube was saturated with ammonia gas at 0° C. The mixture was then heated in an oil bath at 55° C. for two days. The reaction mixture was cooled and evaporated. To the white solid residue was added ether followed by filtration to provide the title compound.

後処理

  1. temperatureThe reaction mixture was cooled
  2. customevaporated
  3. additionTo the white solid residue was added ether
  4. filtrationfollowed by filtration

出典と根拠

ORDレコード
ord-88ac595096ee454cb0c4f32141dd1f42
出典データセット
uspto-grants-2009_09
特許番号
US07582633B2

反応ノート

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