Ammonia → HCID 45380634、化合物
反応式
[Br:1][C:2]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9]2[N:10]=[CH:11][C:12]([C:15](OC)=[O:16])=[N:13][CH:14]=2)[CH2:6]1.[NH3:24]>CO>[Br:1][C:2]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9]2[N:10]=[CH:11][C:12]([C:15]([NH2:24])=[O:16])=[N:13][CH:14]=2)[CH2:6]1参加物
4
反応条件
- 温度
- 50 °C
実験手順
To methyl 5-[3-(2-bromo-5-fluorophenoxy)azetidin-1-yl]pyrazine-2-carboxylate (0.080 g, 2.1 mmol) in MeOH was bubbled ammonia and the mixture was heated at 50° C. After 2 d, the methanol was evaporated followed by the addition of ether. The solid was filtered to provide the title compound as a white solid.
後処理
- customthe methanol was evaporated
- additionfollowed by the addition of ether
- filtrationThe solid was filtered
出典と根拠
- ORDレコード
- ord-7cd9bd263dd8487d8d6f087e9594ac51
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07582633B2
反応ノート
読み込み中…