Sulfamide → 1-(Aminosulfonyl)-N,N-dimethyl-D-prolinamide
反応式
[CH3:1][N:2]([CH3:10])[C:3](=[O:9])[C@H:4]1[CH2:8][CH2:7][CH2:6][NH:5]1.[S:11](N)([NH2:14])(=[O:13])=[O:12]>O1CCOCC1>[NH2:14][S:11]([N:5]1[CH2:6][CH2:7][CH2:8][C@@H:4]1[C:3]([N:2]([CH3:10])[CH3:1])=[O:9])(=[O:13])=[O:12]参加物
4
実験手順
To a solution of the subtitle compound of step ii) (2.20 g) in dioxane (25 ml) was added sulfamide (7.20 g) and the mixture heated at reflux for 45 h. The reaction mixture was cooled and adsorbed on to silica gel and then purified by column chromatography (5% methanol/EtOAc) to afford the subtitle compound as an oil. Yield: 1.6 g.
後処理
- temperaturethe mixture heated
- temperatureat reflux for 45 h
- temperatureThe reaction mixture was cooled
- custompurified by column chromatography (5% methanol/EtOAc)
出典と根拠
- ORDレコード
- ord-13a8a446f25c4281bc402112d714c1d6
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07582644B2
反応ノート
読み込み中…