1-(2-Fluoropyridin-4-yl)-2-(4-fluorophenyl)ethane-1,2-dione-1-oxime → HCID 136335781、化合物
反応式
F[C:2]1[CH:7]=[C:6]([C:8](=[N:18][OH:19])[C:9]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[O:10])[CH:5]=[CH:4][N:3]=1>Cl>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C:9](=[O:10])[C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([O:10][CH:9]([CH3:11])[CH3:8])[CH:7]=2)=[N:18][OH:19])=[CH:12][CH:13]=1参加物
3
実験手順
A solution of 22b (200 mg; 0.76 mmol) in HCl-saturated isopropanol (15 ml) was stirred under reflux for 2.5 h. The solution was concentrated and the yellowish-white residue was triturated with a little ethanol, filtered off and dried.
後処理
- temperatureunder reflux for 2.5 h
- concentrationThe solution was concentrated
- customthe yellowish-white residue was triturated with a little ethanol
- filtrationfiltered off
- customdried
出典と根拠
- ORDレコード
- ord-03f6e56db9ef4a2e934d1d9ecb9141b4
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07582660B2
反応ノート
読み込み中…