化工社化工社 化学情報印刷レポート · 研究参考用
3-Methoxyphenol → 2-(3-Methoxy-phenoxy)-4-(4-trifluoromethyl-phenyl)-pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Methoxyphenol | HCID 9007 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2-Chloro-4-(4-trifluoromethylphenyl)pyridine | HCID 28875863 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(3-Methoxy-phenoxy)-4-(4-trifluoromethyl-phenyl)-pyridine | HCID 57808044 | — |
反応手順
This material was prepared according to the method described in Example 2 (d) using 2-chloro-4-(4-trifluoromethyl-phenyl)-pyridine (Example 410 (c), 129 mg, 0.5 mmol), 3-methoxyphenol (66 uL, 0.6 mmol), and sodium hydride (24 mg, 0.6 mmol) in DMF (1 mL). Purification on a Biotage 40S column (8:1 hexanes:EtOAc), provided the title compound as a white solid. MS (ESI, pos. ion) m/z: 346 (M+1). Mp: 77.5-79.6° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07582657B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-485b61973d254b9d8b8b3f2f9ffb1712 |
| 出典メモ | uspto-grants-2009_09 |