Hydrochloric Acid → HCID 178507533、化合物

HRID 730403ノート

反応式

HRID 730403 の反応式
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]2[NH:15][O:16][C:17](=[O:19])[N:18]=2)[CH:9]=1)(C)(C)C.Cl>CCO>[NH2:7][C:8]1[CH:9]=[C:10]([C:14]2[NH:15][O:16][C:17](=[O:19])[N:18]=2)[CH:11]=[CH:12][CH:13]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 178452711HCID 178452711、化合物

生成物 1

HCID 178507533HCID 178507533、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

A 1 L flask equipped with a magnetic stir bar and heating mantle was charged with [3-(5-oxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl]-carbamic acid tert-butyl ester (60.0 g, 0.22 mol) and EtOH (800 mL). The resulting suspension was then treated with HCl gas (31 g, 0.86 mol) at ambient temperature over 20 minutes. The reaction mixture was then heated to 60° C., until starting material was consumed (1.5 h). The reaction mixture was cooled in an ice-bath and the resulting solid was collected via vacuum filtration. The filter pad was washed with EtOH (75 mL) and air dried to yield the title compound as an off white solid.

後処理

  1. customA 1 L flask equipped with a magnetic stir bar
  2. temperatureheating mantle
  3. customwas consumed (1.5 h)
  4. temperatureThe reaction mixture was cooled in an ice-bath
  5. filtrationthe resulting solid was collected via vacuum filtration
  6. washThe filter pad was washed with EtOH (75 mL) and air
  7. customdried

出典と根拠

ORDレコード
ord-57a3e0e3af5a42dc8f6415504dc4bc30
出典データセット
uspto-grants-2009_09
特許番号
US07582753B2

反応ノート

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