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Iodine chloride → 2-Methoxy-5-Methylaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodine chloride | HCID 24640 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 7-Iodo-N-(2-methoxy-5-methylphenyl)-1-benzofuran-5-sulfonamide | HCID 66892506 | — |
| 生成物 | 2-Methoxy-5-Methylaniline | HCID 8445 | — |
反応手順
7-iodo-N-(2-methoxy-5-methylphenyl)-1-benzofuran-5-sulfonamide is produced starting from 2,3-dihydrobensofuran. Treatment with chlorosulfonic acid gives the corresponding sulfonyl chloride, which is iodinated using iodine monochloride. Aromatization is done using NBS, resulting in 7-iodo-N-(2-methoxy-5-methylphenyl)-1-benzofuran-5-sulfonamide after treatment with cresidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07582767B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-976addb137994549b4eb022567162e52 |
| 出典メモ | uspto-grants-2009_09 |