Ethyl Acrylate → Ethyl 3-(4-piperazin-1-yl-piperidin-1-yl)-propionate

HRID 730639ノート

反応式

HRID 730639 の反応式
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH:2]=[CH2:3].C([N:15]1[CH2:20][CH2:19][N:18]([CH:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)[CH2:17][CH2:16]1)C1C=CC=CC=1>CCO>[N:18]1([CH:21]2[CH2:26][CH2:25][N:24]([CH2:3][CH2:2][C:1]([O:5][CH2:6][CH3:7])=[O:4])[CH2:23][CH2:22]2)[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]1

参加物

4

反応物 2

HCID 8821Ethyl AcrylateHCID 36792751-Benzyl-4-piperidin-4-yl-piperazine

生成物 1

HCID 53791125Ethyl 3-(4-piperazin-1-yl-piperidin-1-yl)-propionate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

5.5 mL (50.8 mmol) ethyl acrylate were added to a solution of 11.7 g (44.9 mmol) 1-benzyl-4-piperidin-4-yl-piperazine in 120 mL dry EtOH and the reaction mixture was refluxed for 1 h and then stirred overnight at RT. The solvent was eliminated i.vac. and the residue was dried for 1 h under an oil pump vacuum. The crude product was reacted further without purification.

後処理

  1. temperaturethe reaction mixture was refluxed for 1 h
  2. customand the residue was dried for 1 h under an oil pump vacuum
  3. customThe crude product was reacted further without purification

出典と根拠

ORDレコード
ord-89b2c71834cb40399d6efd6947977968
出典データセット
uspto-grants-2009_09
特許番号
US07582625B2

反応ノート

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