Hydrochloric Acid → 1-(3-Chloropyridin-2-yl)piperazine hydrochloride

HRID 730706

反応式

HRID 730706 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CO.CCOC(C)=O>[ClH:20].[Cl:20][C:19]1[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[N:15][CH:16]=[CH:17][CH:18]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 11630777Tert-butyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate

生成物 1

HCID 204550741-(3-Chloropyridin-2-yl)piperazine hydrochloride

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of the ester from step (a) above (2.98 g, 10 mmol) in MeOH (5 mL) was added saturated solution of hydrogen chloride in EtOAc (50 mL) and the mixture was stirred at room temperature for 4 h. The solvent was removed in vacuo, and the residue was washed with EtOAc and dried in the air to provide the title compound as a light-yellow solid. MS (ESI, pos. ion) m/z: 198 (M+1).

後処理

  1. customThe solvent was removed in vacuo
  2. washthe residue was washed with EtOAc
  3. customdried in the air

出典と根拠

ORDレコード
ord-2767beb1e38349508ff8e7d7ae456cc1
出典データセット
uspto-grants-2009_09
特許番号
US07582761B2

関連ノート

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