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Diisopropylethylamine → 6-tert-Butyl-2-[4-(3-chloropyridin-4-yl)piperazin-1-yl]-1H-benzoimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 6-tert-Butyl-2-chloro-1H-benzoimidazole | HCID 11586517 | — |
| 反応物 | 1-(3-Chloropyridin-2-yl)piperazine hydrochloride | HCID 20455074 | — |
| 生成物 | 6-tert-Butyl-2-[4-(3-chloropyridin-4-yl)piperazin-1-yl]-1H-benzoimidazole | HCID 67400597 | — |
反応手順
The benzoimidazole from step (b) above (0.209 g, 1 mmol), 1-(3-chloropyridin-2-yl)piperazine hydrochloride (0.304 g, 1.3 mmol, Example 3b) and N,N-diisopropylethylamine (0.45 mL, 2.6 mmol, Aldrich) were reacted under the conditions of Example 1d to give the title compound as a yellow amorphous solid. MS (ESI, pos. ion) m/z: 371 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07582761B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-dc9cb52a50f34f1eb8adb98af13b33b5 |
| 出典メモ | uspto-grants-2009_09 |