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Diisopropylethylamine → 6-Chloro-2-[4-(3-chloropyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 2,5-Dichlorobenzimidazole | HCID 335473 | — |
| 反応物 | 1-(3-Chloropyridin-2-yl)piperazine hydrochloride | HCID 20455074 | — |
| 生成物 | 6-Chloro-2-[4-(3-chloropyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole | HCID 57835093 | — |
反応手順
The 2,5-dichloro-1H-benzoimidazole (0.244 g, 1.3 mmol, Example 20b), 1(3-chloropyridin-2-yl)piperazine hydrochloride (0.4 g, 1.7 mmol, Example 3b) and N,N-diisopropylethylamine (0.59 mL, 3.4 mmol, Aldrich) were reacted under the conditions of Example 3c to give the title compound as a white solid. M.p. 214-215° C. MS (ESI, pos. ion) m/z: 348 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07582761B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-583bb6ff28dd4ad6bae4bfc88fa0927e |
| 出典メモ | uspto-grants-2009_09 |