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Diisopropylethylamine → 2-[4-(3-Chloropyridin-2-yl)piperazin-1-yl]-5,6-dichloro-1H-benzoimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 2,5,6-Trichloro-1H-benzimidazole | HCID 286009 | — |
| 反応物 | 1-(3-Chloropyridin-2-yl)piperazine hydrochloride | HCID 20455074 | — |
| 生成物 | 2-[4-(3-Chloropyridin-2-yl)piperazin-1-yl]-5,6-dichloro-1H-benzoimidazole | HCID 57835109 | — |
反応手順
The 2,5,6-trichloro-1H-benzoimidazole (0.110 g, 0.5 mmol, Example 25b), 1-(3-chloropyridin-2-yl)piperazine hydrochloride (0.234 g, 1 mmol, Example 3b) and N,N-diisopropylethylamine (0.35 mL, 2 mmol, Aldrich) were reacted under the conditions of Example 3c to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 382 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07582761B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-979f9d581a9b4054bd4faec696d3ebd4 |
| 出典メモ | uspto-grants-2009_09 |