tert-Butyl piperazine-1-carboxylate → HCID 11515466、化合物
反応式
Cl[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[C:8]([F:11])([F:10])[F:9].[N:12]1([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>>[C:21]([O:20][C:18]([N:12]1[CH2:17][CH2:16][N:15]([C:2]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[C:8]([F:11])([F:10])[F:9])[CH2:14][CH2:13]1)=[O:19])([CH3:24])([CH3:22])[CH3:23]参加物
3
実験手順
The reaction of 4-chloro-3-trifluoromethylpyridine (2.05 g, 9.4 mmol, Matrix Scientific) and tert-butyl 1-piperazinecarboxylate (2.1 g, 11.3 mmol, Aldrich) under the conditions of Example 3a afforded the crude product, which was purified by silica gel column chromatography (60% EtOAc/hexane) to give the title compound as a white solid. MS (ESI, pos. ion) m/z: 332 (M+1).
後処理
- customafforded the crude product, which
- customwas purified by silica gel column chromatography (60% EtOAc/hexane)
出典と根拠
- ORDレコード
- ord-623a3dd20ae04a37a44b9f6d8495da4a