{5-Chloro-6-[(3R)-3-methylpiperazin-1-yl]pyridin-3-yl}methanol → HCID 178461541、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:15][OH:16])[CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][NH:11][C@H:10]([CH3:14])[CH2:9]1.Cl[C:18]1[NH:22][C:21]2[CH:23]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:25]=[C:26]([I:27])[C:20]=2[N:19]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:15][OH:16])[CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][N:11]([C:18]2[NH:19][C:20]3[C:26]([I:27])=[CH:25][C:24]([C:28]([F:31])([F:29])[F:30])=[CH:23][C:21]=3[N:22]=2)[C@H:10]([CH3:14])[CH2:9]1参加物
3
実験手順
The piperazine from step (a) above (73 mg, 0.3 mmol) reacted with 2-chloro-4-iodo-6-(trifluoromethyl)-1H-benzoimidazole (69 mg, 0.2 mmol, Example 61c) under the conditions of Example 3c to give the title compound as a yellow amorphous solid. MS (ESI, pos. ion) m/z: 552 (M+1).
出典と根拠
- ORDレコード
- ord-4c9ee15684ea4e0098d8f23a6d096772
- 出典データセット
- uspto-grants-2009_09