Phosphorus oxychloride → 2-Chloro-6-(trifluoromethyl)-3H-imidazo[4,5-B]pyridine
反応式
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[C:5]2[NH:11][C:10](=O)[NH:9][C:6]2=[N:7][CH:8]=1.O=P(Cl)(Cl)[Cl:17]>>[Cl:17][C:10]1[NH:11][C:5]2[C:6]([N:9]=1)=[N:7][CH:8]=[C:3]([C:2]([F:14])([F:13])[F:1])[CH:4]=2参加物
3
実験手順
A solution of 6-trifluoromethyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one from step (c) above (161 mg, 0.789 mmol) in POCl3 (5 mL) was heated at 95° C. for 16 h. The reaction mixture was cooled to room temperature, the solvent was removed in vacuo and the resulting oily residue was purified by silica gel column chromatography, eluting with EtOAc/hexane (1:3) to give the title compound as a light-yellow solid. MS (ESI positive ion) m/z: 222 (M+1).
後処理
- customthe solvent was removed in vacuo
- customthe resulting oily residue was purified by silica gel column chromatography
- washeluting with EtOAc/hexane (1:3)
出典と根拠
- ORDレコード
- ord-85827168ede349e38f1315c2197ad4c4
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07582761B2
反応ノート
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