2,3-Dichloro-5-(trifluoromethyl)pyridine → Methyl 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-((1-ethyl-1H-indazol-5-yl)methyl)sulfamoyl)benzoate

HRID 73085

反応式

HRID 73085 の反応式
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1.[CH2:13]([N:15]1[C:23]2[C:18](=[CH:19][C:20]([CH2:24][NH:25][S:26]([C:29]3[CH:38]=[CH:37][C:32]([C:33]([O:35][CH3:36])=[O:34])=[CH:31][CH:30]=3)(=[O:28])=[O:27])=[CH:21][CH:22]=2)[CH:17]=[N:16]1)[CH3:14]>>[Cl:8][C:7]1[C:2]([N:25]([CH2:24][C:20]2[CH:19]=[C:18]3[C:23](=[CH:22][CH:21]=2)[N:15]([CH2:13][CH3:14])[N:16]=[CH:17]3)[S:26]([C:29]2[CH:30]=[CH:31][C:32]([C:33]([O:35][CH3:36])=[O:34])=[CH:37][CH:38]=2)(=[O:28])=[O:27])=[N:3][CH:4]=[C:5]([C:9]([F:12])([F:11])[F:10])[CH:6]=1

参加物

3

反応物 2

HCID 1122342,3-Dichloro-5-(trifluoromethyl)pyridineHCID 66837855Methyl 4-(N-((1-ethyl-1H-indazol-5-yl)methyl)sulfamoyl)benzoate

生成物 1

HCID 66837865Methyl 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-((1-ethyl-1H-indazol-5-yl)methyl)sulfamoyl)benzoate

実験手順

The titled compound was prepared according to the procedure described in step-2 of Example 1 from 2,3-dichloro-5-(trifluoromethyl)pyridine and methyl 4-(N-((1-ethyl-1H-indazol-5-yl)methyl)sulfamoyl)benzoate (step-1 of Example 15).

出典と根拠

ORDレコード
ord-a0c18e34c45a4db28f29b6eaae4083f6
出典データセット
uspto-grants-2014_09
特許番号
US08829026B2

関連ノート

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