2,3,5-Trichloropyridine → (3R)-1-(3,5-Dichloro-pyridin-2-yl)-3-methyl-piperazine

反応式

Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Cl:9])=[CH:4][N:3]=1.[CH3:10][C@@H:11]1[CH2:16][NH:15][CH2:14][CH2:13][NH:12]1>>[Cl:8][C:7]1[C:2]([N:15]2[CH2:14][CH2:13][NH:12][C@H:11]([CH3:10])[CH2:16]2)=[N:3][CH:4]=[C:5]([Cl:9])[CH:6]=1

参加物

反応物 2

HCID 276662,3,5-Trichloropyridine

HCID 73304342-Methylpiperazine, (R)-

生成物 1

HCID 67402021(3R)-1-(3,5-Dichloro-pyridin-2-yl)-3-methyl-piperazine

実験手順

2,3,5-Trichloro-pyridine (910 mg, 5.0 mmol, Aldrich) and (R)-(−)-2-methyl-piperazine (700 mg, 7.0 mmol, Aldrich) reacted under the conditions of Example 3a to give the title compound as a light-yellow solid. MS (ESI, pos. ion) m/z: 247 (M+1).

出典と根拠

ORDレコード: ord-231e01cfcf4e4e48adef34930f4cf57d
出典データセット: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07582761B2

反応ノート

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