Methylamine → [(5,6-Dichloropyridin-3-yl)methyl](methyl)amine

HRID 730868ノート

反応式

HRID 730868 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][N:10]2C(=O)C3C(=CC=CC=3)[C:11]2=O)[CH:5]=[N:6][C:7]=1[Cl:8].CN>CCO>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][NH:10][CH3:11])[CH:5]=[N:6][C:7]=1[Cl:8]

参加物

4

反応物 2

HCID 6329MethylamineHCID 859654402-(5,6-Dichloro-pyridin-3-ylmethyl)-isoindole-1,3-dione

生成物 1

HCID 85663685[(5,6-Dichloropyridin-3-yl)methyl](methyl)amine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2-(5,6-dichloro-pyridin-3-ylmethyl)-isoindole-1,3-dione from step (b) above (307 mg, 1.0 mmol) and methylamine (1.0 mL, 2.0 mmoL, 2.0 M in THF, Aldrich) in EtOH (10 mL) was stirred at room temperature for 4 days. The solvent was removed in vacuo to give the title compound, which was used in the next step without additional purification.

後処理

  1. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-d017c469903d45a7981b285fe0ac1cfc
出典データセット
uspto-grants-2009_09
特許番号
US07582761B2

反応ノート

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