2-Methylpiperazine, (R)- → N-[5-Chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-ylmethyl]-N-methyl-acetamide

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][N:10]([CH3:14])[C:11](=[O:13])[CH3:12])[CH:5]=[N:6][C:7]=1Cl.[CH3:15][C@@H:16]1[CH2:21][NH:20][CH2:19][CH2:18][NH:17]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][N:10]([CH3:14])[C:11](=[O:13])[CH3:12])[CH:5]=[N:6][C:7]=1[N:20]1[CH2:19][CH2:18][NH:17][C@H:16]([CH3:15])[CH2:21]1

参加物

反応物 2

HCID 73304342-Methylpiperazine, (R)-

HCID 77230301N-(5,6-Dichloro-pyridin-3-ylmethyl)-N-methyl-acetamide

生成物 1

HCID 67401544N-[5-Chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-ylmethyl]-N-methyl-acetamide

実験手順

A mixture of N-(5,6-dichloro-pyridin-3-ylmethyl)-N-methyl-acetamide from step (a) above (233 mg, 1.0 mmol) and (R)-(−)-2-methyl-piperazine (110 mg, 1.1 mmol, Aldrich) reacted under the conditions of Example 3a to give the title compound. MS (ESI, pos. ion) m/z: 297 (M+1).

後処理

customreacted under the conditions of Example 3a

出典と根拠

ORDレコード: ord-1c547edc9d9343a898f4355921d6044e
出典データセット: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07582761B2

反応ノート

読み込み中…

参加物