Methyl 4-(Chlorosulfonyl)benzoate → Methyl 4-(N-((1-(2-hydroxy-2-methylpropyl)-1H-indazol-5-yl)methyl)sulfamoyl)benzoate

反応式

Cl[S:2]([C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[NH2:15][CH2:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[N:22]([CH2:26][C:27]([CH3:30])([OH:29])[CH3:28])[N:21]=[CH:20]2>>[OH:29][C:27]([CH3:30])([CH3:28])[CH2:26][N:22]1[C:23]2[C:19](=[CH:18][C:17]([CH2:16][NH:15][S:2]([C:5]3[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=3)(=[O:4])=[O:3])=[CH:25][CH:24]=2)[CH:20]=[N:21]1

参加物

反応物 2

HCID 4738388Methyl 4-(Chlorosulfonyl)benzoate

HCID 66837937HCID 66837937、化合物

生成物 1

HCID 66837918Methyl 4-(N-((1-(2-hydroxy-2-methylpropyl)-1H-indazol-5-yl)methyl)sulfamoyl)benzoate

実験手順

The titled compound was prepared according to the procedure described in step-1 of Example 1 from methyl 4-(chlorosulfonyl)benzoate and 1-(5-(aminomethyl)-1H-indazol-1-yl)-2-methylpropan-2-ol (step-2 of Example 22).

出典と根拠

ORDレコード: ord-5ed59552897d4ef98e8335cf13944003
出典データセット: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08829026B2

反応ノート

読み込み中…