p-Toluenesulfonic acid monohydrate → (2R,3R)-1-Chloro-2-(2,4-difluorophenyl)butane-2,3-diol
反応式
[Cl:1][CH2:2][C@:3]([C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=1[F:21])([OH:13])[C@H:4]([O:6]C1CCCCO1)[CH3:5].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[Cl:1][CH2:2][C@:3]([C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=1[F:21])([OH:13])[C@H:4]([OH:6])[CH3:5]参加物
4
実験手順
A mixed solution of 0.15 g (0.47 mmol) of (2R,3R)-1-chloro-2-(2,4-difluorophenyl)-3-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)butan-2-ol, 5 mL of methanol, and 0.02 g of p-toluenesulfonic acid monohydrate was stirred at room temperature for 30 minutes. Concentration was performed under reduced pressure to obtain a crude product. The resulting product was purified by column on silica gel to obtain 0.12 g of the title compound (yield: 97%).
後処理
- concentrationConcentration
- customto obtain a crude product
- customThe resulting product was purified by column on silica gel
出典と根拠
- ORDレコード
- ord-a46471aa06364ff59d00bf45c253c3e8
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07582781B2
反応ノート
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