Salicylic Acid → 2,4-Di-tert-butylphenol

HRID 731126

反応式

HRID 731126 の反応式
[C:1]([C:5]1[CH:13]=[C:12]([C:14]([CH3:17])([CH3:16])[CH3:15])[CH:11]=[C:7](C(O)=O)[C:6]=1[OH:18])([CH3:4])([CH3:3])[CH3:2].C(O)(=O)C1C(=CC=CC=1)O>C(C1C=C(C(C)(C)C)C=C(C([O-])=O)C=1O)(C)(C)C.[Zn+2].C(C1C=C(C(C)(C)C)C=C(C([O-])=O)C=1O)(C)(C)C.[Zn]>[C:1]([C:5]1[CH:13]=[C:12]([C:14]([CH3:17])([CH3:16])[CH3:15])[CH:11]=[CH:7][C:6]=1[OH:18])([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 2

HCID 338Salicylic AcidHCID 882083,5-Bis(1,1-dimethylethyl)-2-hydroxybenzoic acid3 回

生成物 1

HCID 73112,4-Di-tert-butylphenol

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 131879255Bis[3,5-di-tert-butyl-2-(hydroxy-kappaO)benzoato-kappaO]zinc触媒

実験手順

Referring to 3,5-di-tert-butylsalicylic acid as an example salicylic acid derivative, it is possible to selectively synthesize zinc 3,5-di-tert-butylsalicylate by adding drop by drop a solution containing a zinc provider to a solution of 3,5-di-tert-butylsalicylic acid in alkali to cause the reaction. For example, a sufficient amount of an alkaline aqueous solution is added to 2 mol of 3,5-di-tert-butylsalicylic acid (produced from the starting material 2,4-di-tert-butylphenol by the Kolbe-Schmitt reaction) and dissolved with heating. Separately, an aqueous solution incorporating 1 mol of a zinc provider is prepared. While heating this aqueous solution, the aforementioned aqueous solution of 3,5-di-tert-butylsalicylic acid is added drop by drop, and the reaction is carried out with heating and pH adjustment; after completion of the reaction, the reaction mixture is filtered and the cake filtered off is washed with water and dried. Examples of zinc providers include, but are not limited to, zinc sulfate, zinc chloride and zinc acetate.

後処理

  1. additionby adding drop by drop a solution
  2. customthe reaction

出典と根拠

ORDレコード
ord-1aa10f343f714ae19b3e952762c4c233
出典データセット
uspto-grants-2009_09
特許番号
US07582787B2

関連ノート

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