Ammonia → 1-Amino-3-(morpholin-4-yl)propan-2-ol

HRID 731145

反応式

HRID 731145 の反応式
Cl[CH2:2][CH:3]([OH:11])[CH2:4][N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1.[NH3:12]>CO>[NH2:12][CH2:2][CH:3]([OH:11])[CH2:4][N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1

参加物

4

反応物 2

HCID 222AmmoniaHCID 100809871-Chloro-3-morpholin-4-yl-propan-2-ol

生成物 1

HCID 28322311-Amino-3-(morpholin-4-yl)propan-2-ol収率 91%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1-Chloro-3-morpholin-4-yl-propan-2-ol (2.0 g, 11 mmol) was treated with the solution of NH3 in methanol (25% by weight, 20 mL) at room temperature. Nitrogen was bulbbed into the reaction mixture to remove the ammonia. Evaporation of solvent gave the hydrogen chloride salt of 1-amino-3-morpholin-4-yl-propan-2-ol (2.0 g, 91%). 1H NMR (DMSO-d6) δ 2.30 (d, J=6.0 Hz, 2H), 2.36 (m, 4H, NCH2), 2.65 (dd, J=8.4, 12.8 Hz, 1H), 2.91 (dd, J=3.6, 12.8 Hz, 1H), 3.52 (m, 4H, OCH2), 3.87 (m, 1H, CH), 5.32 (s, 1H, OH), 8.02 (brs., 3H, NH3+). MS (m/z) 161.1 (M+1).

後処理

  1. customto remove the ammonia
  2. customEvaporation of solvent

出典と根拠

ORDレコード
ord-f32a112c72d849d88683b2764010a6e9
出典データセット
uspto-grants-2009_09
特許番号
US07582756B2

関連ノート

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