2,3-Dichloro-5-(trifluoromethyl)pyridine → Ethyl 3-chloro-4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-((1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)sulfamoyl)benzoate

HRID 73119ノート

反応式

HRID 73119 の反応式
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1.[Cl:13][C:14]1[CH:15]=[C:16]([CH:22]=[CH:23][C:24]=1[S:25](=[O:39])(=[O:38])[NH:26][CH2:27][C:28]1[CH:29]=[C:30]2[CH:36]=[CH:35][N:34]([CH3:37])[C:31]2=[N:32][CH:33]=1)[C:17]([O:19][CH2:20][CH3:21])=[O:18]>>[Cl:13][C:14]1[CH:15]=[C:16]([CH:22]=[CH:23][C:24]=1[S:25](=[O:38])(=[O:39])[N:26]([C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1)[CH2:27][C:28]1[CH:29]=[C:30]2[CH:36]=[CH:35][N:34]([CH3:37])[C:31]2=[N:32][CH:33]=1)[C:17]([O:19][CH2:20][CH3:21])=[O:18]

参加物

3

反応物 2

HCID 1122342,3-Dichloro-5-(trifluoromethyl)pyridineHCID 66837935HCID 66837935、化合物

生成物 1

HCID 66837913Ethyl 3-chloro-4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-((1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)sulfamoyl)benzoate

実験手順

The titled compound was prepared according to the procedure described in step-2 of Example 1 from 2,3-dichloro-5-(trifluoromethyl)pyridine and ethyl 3-chloro-4-(N-((1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)sulfamoyl)benzoate (step-2 of Example 35).

出典と根拠

ORDレコード
ord-ae8627b6dd874eb79da61783746556ef
出典データセット
uspto-grants-2014_09
特許番号
US08829026B2

反応ノート

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