Acetyl chloride → N'-Allyl-N'-cyclobutyl-hydrazine hydrochloride

HRID 731348ノート

反応式

HRID 731348 の反応式
C([Cl:4])(=O)C.C(OC([NH:12][N:13]([CH2:18][CH:19]=[CH2:20])[CH:14]1[CH2:17][CH2:16][CH2:15]1)=O)(C)(C)C>CO>[ClH:4].[CH2:18]([N:13]([CH:14]1[CH2:17][CH2:16][CH2:15]1)[NH2:12])[CH:19]=[CH2:20]

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 57671220N'-allyl-N'-cyclobutyl-hydrazinecarboxylic acid tert-butyl ester

生成物 1

HCID 69061160N'-Allyl-N'-cyclobutyl-hydrazine hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
25 °C

実験手順

Acetyl chloride (1.45 mL, 20.41 mmol) was added dropwise into methanol (10 mL) at 0° C. The resulting mixture was stirred at 25° C. for 30 min. N′-allyl-N′-cyclobutyl-hydrazinecarboxylic acid tert-butyl ester (0.40 g, 1.77 mmol) was added in one portion. The reaction was stirred at 25° C. for 18 h. The mixture was concentrated in vacuo and used directly in the next step.

後処理

  1. stirringThe reaction was stirred at 25° C. for 18 h
  2. concentrationThe mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-4b4a5ccc34fd4c86bd3f18d9761613e0
出典データセット
uspto-grants-2009_09
特許番号
US07582626B2

反応ノート

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