Butyryl chloride → Thiobutyric acid S-(1-phenyl-ethyl)ester

HRID 731503

反応式

HRID 731503 の反応式
[SH:1][CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH3:3].[C:10](Cl)(=[O:14])[CH2:11][CH2:12][CH3:13]>>[C:4]1([CH:2]([S:1][C:10](=[O:14])[CH2:11][CH2:12][CH3:13])[CH3:3])[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

3

反応物 2

HCID 8855Butyryl chlorideHCID 1418501-Phenylethanethiol

生成物 1

HCID 86595377Thiobutyric acid S-(1-phenyl-ethyl)ester収率 98%

実験手順

At room temperature, 13.8 g of 1-mercapto-1-phenylethane is dissolved in 50 mL of butyryl chloride. The mixture is stirred at room temperature for 6 hours. It is then cooled down to 0° C. and the reaction is quenched by careful addition of 100 ml of dry methanol in small portions. The mixture is then washed with bicarbonate, dried over magnesium sulfate, filtered and concentrated to give the butyrated compound in 98% yield.

後処理

  1. temperatureIt is then cooled down to 0° C.
  2. customthe reaction is quenched by careful addition of 100 ml of dry methanol in small portions
  3. washThe mixture is then washed with bicarbonate
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customto give the butyrated compound in 98% yield

出典と根拠

ORDレコード
ord-495643dbcb4a4b69880cb975f4aba0a8
出典データセット
uspto-grants-2009_09
特許番号
US07585535B2

関連ノート

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