化工社化工社 化学情報印刷レポート · 研究参考用
Lithium Hexamethyldisilazide → 4-(4-(3,3-Diphenyl-2-propenyl)-1-piperazinyl)benzenecarboximidamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| 反応物 | 4-(4-(3,3-Diphenyl-2-propenyl)-1-piperazinyl)benzonitrile | HCID 59186611 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-(4-(3,3-Diphenyl-2-propenyl)-1-piperazinyl)benzenecarboximidamide | HCID 59186607 | 83.4% |
反応手順
A solution of EXAMPLE 12A (0.515 g, 1.36 mmol) in dry tetrahydrofuran (6 mL) was treated dropwise with LiHMDS (1M, 6.8 mL, 6.8 mmol), stirred for 16 hours, quenched with 1N HCl (8 mL), and filtered. The filter cake was collected to provide the desired product (0.45 g, 71%) that was used without further purification. MS (CI) m/e 397 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07585858B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-f615de3334bf4e5d8dc073a1350c2764 |
| 出典メモ | uspto-grants-2009_09 |