Aluminium lithium hydride → 2-(1H-pyrrolo[2,3-c]pyridin-3-yl)ethanamine
反応式
O=[C:2]([C:6]1[C:14]2[C:9](=[CH:10][N:11]=[CH:12][CH:13]=2)[NH:8][CH:7]=1)[C:3]([NH2:5])=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>CCOCC>[NH2:5][CH2:3][CH2:2][C:6]1[C:14]2[C:9](=[CH:10][N:11]=[CH:12][CH:13]=2)[NH:8][CH:7]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
A solution of 2-oxo-2-(1H-pyrrolo[2,3-c]pyridin-3-yl)acetamide (1 eq.) in ether is treated with lithium aluminum hydride (4 eq.), heated at reflux temperature for 8 h, cooled to 0° C. and quenched by addition of Rochelle's salt solution. The reaction mixture is extracted with CH2Cl2; the combined extracts are dried over MgSO4 and concentrated in vacuo to afford the title 6-azatryptamine product, which is used directly in step 4, below.
後処理
- temperatureheated
- temperatureat reflux temperature for 8 h
- customquenched by addition of Rochelle's salt solution
- extractionThe reaction mixture is extracted with CH2Cl2
- dry with materialthe combined extracts are dried over MgSO4
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-a6b8d35b26824a86a8cd8298a86aa4d1
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07585876B2
反応ノート
読み込み中…