関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | 2-Bromopropanedial | HCID 74945 | — |
| 反応物 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 溶媒 | Cyclohexane | HCID 8078 | — |
| 生成物 | 2-Bromo-3-isopropoxy-propenal | HCID 53416634 | — |
反応手順
A mixture of 2-bromomalonaldehyde, para-toluenesulfonic acid monohydrate, 2-propanol and cyclohexane were stirred at 86° C. in flask with a dean-stark trap under azeotropic conditions. Further distillation removed another 40% of the original solvent volume. The mixture was cooled to 0° C., then concentrated in-vacuo, to isolate the title compound (13.2 g). 1H-NMR: 9.16 (s, 1H), 7.65 (s, 1H), 4.51 (m, 1H), 1.47 (d, 6H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07585881B2 |
|---|
| 出典データセット | uspto-grants-2009_09 |
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| ORD ID | ord-e8d5ea4059e54f579482ffe59c821d7e |
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| 出典メモ | uspto-grants-2009_09 |
|---|
