(+)-4-(5-{1-[5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl]propoxy}-4-methyl-4H-1,2,4-triazol-3-yl)pyridine → (+)-1-[5-(3-Chlorophenyl)-[1,2,4]oxadiazol-3-yl]propan-1-ol

反応式

ClC1C=C(C2ON=C([C@H](O)C)N=2)C=CC=1.[Cl:16][C:17]1[CH:18]=[C:19]([C:23]2[O:27][N:26]=[C:25]([CH:28]([O:31]C3N(C)C(C4C=CN=CC=4)=NN=3)[CH2:29][CH3:30])[N:24]=2)[CH:20]=[CH:21][CH:22]=1>>[Cl:16][C:17]1[CH:18]=[C:19]([C:23]2[O:27][N:26]=[C:25]([CH:28]([OH:31])[CH2:29][CH3:30])[N:24]=2)[CH:20]=[CH:21][CH:22]=1

参加物

反応物 2

HCID 11661227(+)-4-(5-{1-[5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl]propoxy}-4-methyl-4H-1,2,4-triazol-3-yl)pyridine

HCID 57837962(+)-(1R)-1-[5-(3-chlorophenyl)-[1,2,4]oxadiazol-3-yl]ethanol

生成物 1

HCID 57837988(+)-1-[5-(3-Chlorophenyl)-[1,2,4]oxadiazol-3-yl]propan-1-ol

実験手順

The title compound was synthesized analogous to (+)-(1R)-1-[5-(3-chlorophenyl)-[1,2,4]oxadiazol-3-yl]ethanol and was used directly in the next step for (+)-4-(5-{1-[5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl]propoxy}-4-methyl-4H-1,2,4-triazol-3-yl)pyridine.

出典と根拠

ORDレコード: ord-6c834eab4dc1454eb14cc1274d592efb
出典データセット: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07585881B2

反応ノート

読み込み中…

参加物